Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement

Goode, Roy A.; Hum, Julia M.; Kalwat, M.

doi:10.1210/endocr/bqac193

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Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement

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MLA citation style (9th ed.)

Goode, Roy A, Hum, Julia M, and Kalwat, M. Therapeutic Strategies Targeting Pancreatic Islet Β-cell Proliferation, Regeneration, and Replacement. Oxford University Press on behalf of the Endocrine Society. 2022. marian.hykucommons.org/concern/generic_works/1414f5c4-7dac-4fe9-957f-fd0ead4388be?q=DOI:%20https://doi.org/10.1016/j.zool.2021.125961.

APA citation style (7th ed.)

G. R. A, H. J. M, & K. M. (2022). Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement. https://marian.hykucommons.org/concern/generic_works/1414f5c4-7dac-4fe9-957f-fd0ead4388be?q=DOI:%20https://doi.org/10.1016/j.zool.2021.125961

Chicago citation style (CMOS 17, author-date)

Goode, Roy A., Hum, Julia M., and Kalwat, M.. Therapeutic Strategies Targeting Pancreatic Islet Β-Cell Proliferation, Regeneration, and Replacement. Oxford University Press on behalf of the Endocrine Society. 2022. https://marian.hykucommons.org/concern/generic_works/1414f5c4-7dac-4fe9-957f-fd0ead4388be?q=DOI:%20https://doi.org/10.1016/j.zool.2021.125961.

Note: These citations are programmatically generated and may be incomplete.

Diabetes results from insufficient insulin production by pancreatic islet β-cells or a loss of β-cells themselves. Restoration of regulated insulin production is a predominant goal of translational diabetes research. Here, we provide a brief overview of recent advances in the fields of β-cell proliferation, regeneration, and replacement. The discovery of therapeutic targets and associated small molecules has been enabled by improved understanding of β-cell development and cell cycle regulation, as well as advanced high-throughput screening methodologies. Important findings in β-cell transdifferentiation, neogenesis, and stem cell differentiation have nucleated multiple promising therapeutic strategies. In particular, clinical trials are underway using in vitro–generated β-like cells from human pluripotent stem cells. Significant challenges remain for each of these strategies, but continued support for efforts in these research areas will be critical for the generation of distinct diabetes therapies.

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